However, Singh et al. recently observed a very high expression of Fibroblast Growth Factor Receptor 2-IIIc isoform (FGFR2-IIIC) and twist family bHLH transcription factor 1 (TWIST1) in GCT stromal cells, suggesting that they play an essential role in these cells [18]. The gene discussed is TWIST1; the disease is granular cell tumor.