Mesothelioma cells were selected to ectopically express a dominant active form of 4E-BP1 with residues threonine 37 and 46 replaced with alanines (4E-BP1A37/A46), rendering the resulting protein insensitive to phosphorylation and thus constitutively active in its repressor function. This evidence concerns the gene EIF4EBP1 and mesothelioma.