Thus, while HGF (or fibroblasts) do not further stimulate MET signaling (Supplementary Figures 3B and 5A) or promote the viability (Figure 3) in MET-amplified cancer cells, our results established that MET-amplified NSCLC cells become addicted to HGF upon pharmacological MET inhibition. The gene discussed is MET; the disease is non-small cell lung carcinoma.