To assess the impact of SAV1 expression on pancreatic cancer migration and invasion, the transfected PANC-1 cells were wounded by scratching and the results showed that the silencing of SAV1 promoted PANC-1 cells flattening and spreading (Figure 3A1, *, P<0.05), while ectopic expression of SAV1 in AsPC-1 cells wounded by scratching resulted in a decreased cell flattening and spreading (Figure 3B1, *P<0.05). This evidence concerns the gene SAV1 and familial pancreatic carcinoma.