We noted that these pathways signature uncovered involvement in cytokine-cytokine receptor interaction, TGFβ signaling pathway, Hippo signaling pathway, and also pointed to central roles for COL1A1, COL27A1 and BMPR2. Though some relationship between these genes and cancer has been proposed in other systems [19], our network reveals that this mechanism may also contribute to resistance in lung cancer (Figure 5). This evidence concerns the gene COL27A1 and cancer.