Among the 253 haplotype blocks tested for their association with HCC risk only one reached array-wide significance and was located in the BRIP1 locus (BRCA1 interacting protein C-terminal helicase 1; Gene ID: 83990; formerly known as BACH1 or FANCJ) in the chromosome 17q23 (Chi-Squared SV Perm, P=5.00×10−4) (See Supplemental Table S3 in the supplementary appendix). This evidence concerns the gene BRIP1 and hepatocellular carcinoma.