Using multivariate Cox proportional-hazards regression analysis, the three BRIP1 variants were independently associated with time to HCC occurrence after adjusting for age, sex, body mass index, alcohol consumption, aminotransferase level, viral cirrhosis etiology, and the top eigenvalue obtained from the primary component analysis in order to adjust for potential population admixture (rs4986763, adjusted HR, 1.62; 95% CI, 1.06 to 2.47; P=2.6×10−2; rs4986764, adjusted HR, 1.60; 95% CI, 1.05 to 2.44; P=3.2×10−2; rs4986765, adjusted HR, 1.57; 95% CI, 1.03 to 2.42; P=3.8×10−2) (Figure 2). Here, BRIP1 is linked to hepatocellular carcinoma.