At the genetic variant level, on the three BRIP1 variants tested for their association with HCC risk, only rs4986765 was significantly associated with HCC risk (odds ratio, 6.18; 95% CI, 4.03 to 9.49; P=6.42×10−18; FDR-P=1.93×10−17) (Table 4). The gene discussed is BRIP1; the disease is hepatocellular carcinoma.