At the genetic variant level, on the three BRIP1 variants tested for their association with HCC risk, only rs4986765 was significantly associated with HCC risk (odds ratio, 1.69; 95% CI, 1.08 to 2.63; P=2.19×10−2; FDR-P=6.56×10−2) (Table 4). The gene discussed is BRIP1; the disease is hepatocellular carcinoma.