In post-hoc exploratory analysis, haplotype trend regression was carried out in order to estimate the influence of HCV genotype on the association between BRIP1 haplotypes and HCC phenotype in a subset of patients with available data from the Derivation#2 study (23 cases from CiRCE and 970 controls from the ANRS Genoscan and Swiss Hepatitis C Cohort Studies). Here, BRIP1 is linked to hepatocellular carcinoma.