Conversely, the BRIP1 ‘GGG’ haplotype (simultaneous occurrence of the major allele for each one of the three BRIP1 variants) was associated with a decreased HCC risk (EM frequency in cases, 45%; EM frequency in controls, 66%; odds ratio, 0.42; 95% CI, 0.26 to 0.69; P=5.09×10−4; FDR-P=1.53×10−3) (Table 3, Figure 1, and Supplemental Figure S1 in the supplementary appendix). The gene discussed is BRIP1; the disease is hepatocellular carcinoma.