In multivariate logistic regression analysis, the three BRIP1 variants were independently associated with HCC risk after adjusting for age, sex, body mass index, alcohol consumption, alanine aminotransferase level, disease duration of cirrhosis, viral cirrhosis etiology, and the top eigenvalue obtained from the primary component analysis in order to adjust for potential population admixture (rs4986763, adjusted OR, 2.52; 95% CI, 1.37 to 4.61; P=2.9×10−3; rs4986764, adjusted OR, 2.50; 95% CI, 1.36 to 4.59; P=3.2×10−3; and rs4986765, adjusted OR, 2.18; 95% CI, 1.17 to 4.06; P=1.4×10−2). This evidence concerns the gene GPT and Cirrhosis.