BRIP1 is a DNA-dependent ATPase and a 5′-to-3′ DNA helicase that achieves its cancer suppression function and DNA double-strand break repair through direct interaction with the highly conserved, C-terminal BRCT (BRCA1 C-Terminal domain) protein domain repeats of the tumor suppressor BRCA1 [24, 25]. Here, BRCA1 is linked to cancer.