The BRIP1 ‘AAA’ haplotype was associated with an increased risk of HCC (EM frequency in cases, 28%; EM frequency in controls, 18%; odds ratio, 1.71; 95% CI, 1.09 to 2.68; P=1.82×10−2; FDR-P=7.30×10−2) (Table 3). The gene discussed is BRIP1; the disease is hepatocellular carcinoma.