Among the three different haplotypes of the BRIP1 haplotype block, the ‘AAA’ haplotype (simultaneous occurrence of the minor allele for each one of the three BRIP1 variants) was associated with an increased risk of HCC (EM frequency in cases, 38%; EM frequency in controls, 24%; odds ratio, 2.01; 95% CI, 1.19 to 3.39; P=8.74×10−3; FDR-P=1.31×10−2). The gene discussed is BRIP1; the disease is hepatocellular carcinoma.