SQSTM1 and neoplasm: Consistently, analysis of gene expression value from The Cancer Genome Atlas (TCGA) showed that p62 mRNA expression levels in normal tissues (n = 110) were significantly lower than that in both primary tumour (n = 1065; −0.4355 versus −0.1485) and metastatic tumour tissues (n = 7; −0.4355 versus −0.1423) (Figure 1B).