The expressions of upstream survival signals (GSK-3β, β-catenin, c-Myc and cyclin D1), downstream ABC transporters, including P-gp and MRPs, and apoptosis-related proteins, such as Bcl-2, Bax, and caspases in colon cancer cells were assessed after Epi treatment in the presence and absence of HuR knockdown or overexpression. This evidence concerns the gene ELAVL1 and malignant colon neoplasm.