GSK3B and malignant colon neoplasm: In our previous study, we showed for the first time that the treatment of siRNA against galectin-3 sensitized MDR cells to Epi by inhibiting P-gp and MRPs and the activation of the mitochondrial apoptosis pathway through modulation of the β-catenin/GSK-3β pathway in human colon cancer Caco-2 cells [17].