ELAVL1 and malignant colon neoplasm: We further found that HuR silencing decreased MDR transporter expressions (Figs 4G and 7), enhanced Epi cellular accumulation (Fig 4A) and induced apoptosis pathway (Figs 5A, 5C, 5E, 6A, 6C, 6E and 7), leading to the increased cytotoxic effect of Epi on colon cancer cells (Fig 2B).