Among them, β-catenin is critical in regulating Wnt signaling pathway by entering the nucleus and binding to T-cell factor/lymphoid enhancer factor (TCF/LEF) and activating their specific target genes including c-Myc, cyclin D1, MDR1 in colon cancer and chronic myeloid leukemia (CML) cells [18,33,34]. This evidence concerns the gene HNF4A and chronic myelogenous leukemia, BCR-ABL1 positive.