On the other hand, Ouyang et al observed that IRF-8 deficient mice have enhanced Th17 cell differentiation in vitro and adoptive transfer of naïve CD4+ T cells from Irf8-/- mice results in enhanced Th17 responses and more severe intestinal inflammation in a Rag-/- mouse model of colitis than cells from control mice [19]. Here, IRF8 is linked to colitis.