To nevertheless address whether the ability of p21CIP1 to inhibit replication is key to addiction of high-risk HPV E7 expressing cells to KDM6A, we assessed whether depleting the DNA licensing factors CDC7/DBF4 in SiHa cervical cancer cells might abrogate the KDM6A-mediated decrease in cell viability. The gene discussed is CDKN1A; the disease is cervical carcinoma.