We observed a consistent and significant delay in Aim2-/- macrophage death upon treatment with a caspase-11 siRNA (Fig 3C and 3D and S4B Fig) indicating that while F. novicida is largely able to escape caspase-11 detection ([36], Fig 3E, S4C and S4D Fig), caspase-11 may contribute to macrophage cell death at late time points of the infection in the absence of AIM2. The gene discussed is AIM2; the disease is infection.