These results demonstrate that tumor cell media may modulate expression levels of FGFRs in an isoform dependent manner and that although the magnitude of change in Fgfr1 isoforms is minimal, Fgfr2 and Fgfr3 isoforms are altered, possibility leading to differential sensitivity of osteoclasts to different ligands. This evidence concerns the gene FGFR1 and neoplasm.