However, treatment of osteoclasts with BGJ398 reduced activation of p38 and pERK by both MDA-MB-231 and BoM-1833 cells and pAkt by the BoM-1833 cells (Fig 2), suggesting that FGFR activity contributes to activation of these pathways in osteoclasts following exposure to tumor cell conditioned media. Here, EIF2AK3 is linked to neoplasm.