In addition, tetraploidy and TP53 mutations tend also to be concomitant with over-expression of metabolic (GMPS) and cell-growth modulating genes (TSPYL5, NDRG1 and FOXM1) [36], favoring tumor progression and metastasis, as well as higher expression of APOBEC3B, which promotes mutational heterogeneity within tumors and, thereby, their drug resistance through subclonal selection [37]. Here, TSPYL5 is linked to neoplasm.