CXCL8 and neoplasm: Previous studies have suggested that IL-8 promoted malignant tumor growth and metastasis in an autocrine and paracrine manner.32, 33 In addition, tumor-derived IL-8 activated ECs in the tumor vasculature to promote angiogenesis.34 Our subsequent proteome profiler array on the lysate of cells indicated that the HT-29 CM-induced NECs highly expressed IL-8 compared with NECs.