Downregulation of tonic GABAergic inhibition was previously reported in subiculum (Curia et al., 2009) and amygdala (Olmos-Serrano et al., 2010; Martin et al., 2014) in Fmr1 KO mice, a mouse model of fragile X syndrome, which also exhibits autism-related behaviors. Here, FMR1 is linked to fragile X syndrome.