Since tonic inhibition is found to be involved in the generation of gamma oscillations (Mann and Mody, 2010) and altered tonic inhibition also contributes to epilepsy (Roberts et al., 2005; Ferando and Mody, 2012; Lee and Liou, 2013), the decreased tonic inhibition in Cntnap2 KO mice observed in the current study suggests an underlying mechanism for those phenotypes in individuals with autism. The gene discussed is CNTNAP2; the disease is epilepsy.