In the orthotopic model of HNSCC, tumors were established in all tested groups, but the incidence of lymphovascular metastasis was enhanced in the CAF-injected groups (Figure 3B), and immunohistochemical staining for LYVE-1 confirmed the lymphatic micro-localization of metastatic deposits in the cervical soft tissues and in the peri-vascular spaces (Figure 3C). The gene discussed is LYVE1; the disease is head and neck squamous cell carcinoma.