SPARCL1 codes for a secreted glycoprotein which regulates extracellular matrix (ECM) and cell-matrix adhesion (Girard and Springer, 1996) SPARCL1 inhibits cell proliferation and migration and reduced SPARCL1 expression has been linked to cancer metastases (Nelson et al., 1998; Sullivan and Sage, 2004). This evidence concerns the gene SPARCL1 and cancer.