BRCA1 and hereditary nonpolyposis colon cancer: Different mutations in the DNA repair machinery lead to hereditary cancers syndromes such as hereditary non-polyposis colorectal cancer (HNPCC)[8], breast and ovarian cancer with hereditary mutations in BRCA1 and BRCA2 [9] and familial adenomatous polyposis with an almost 100% lifetime risk of colorectal cancer[10].