Ischemic stroke induced oligodendrocytic damage and progressive demyelination of axons, characterized with increased SMI-32 staining and decreased MBP staining in the peri-infarct regions of the ipsilateral striatum and corpus callosum, and thus reflected by the persistent increase in the SMI-32/MBP ratio in N3L-fed aged mice at 56 days after MCAO compared to sham (Fig. 5C,D). This evidence concerns the gene MBP and ischemic stroke.