To better understand their roles in brain development and malignancies, we performed bioinformatic analyses of the expression of PJA1 and PJA2 across 29 cancers in the TCGA databases and found that both PJA1 and PJA2 are highly expressed in brain malignancies including Glioblastoma (GBM) and Gliomas (Figure 1A) [8]. The gene discussed is PJA2; the disease is central nervous system cancer.