Indeed, a number of mechanistic studies demonstrated that acute pharmacologic ganglionic blockade by trimetaphan is able to reduce blood pressure (Shibao et al., 2007), to improve insulin sensitivity (Gamboa et al., 2014) and to reverse endothelial function (Gamboa et al., 2016) in obesity, in particular if associated with hypertension. Here, INS is linked to hypertensive disorder.