Indeed, a number of mechanistic studies demonstrated that acute pharmacologic ganglionic blockade by trimetaphan is able to reduce blood pressure (Shibao et al., 2007), to improve insulin sensitivity (Gamboa et al., 2014) and to reverse endothelial function (Gamboa et al., 2016) in obesity, in particular if associated with hypertension. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.