Based on this piece of evidence, Mark et al. suggested that some forms of obesity may be characterized by a “selective leptin resistance,” limited to its favorable metabolic effects (satiety and weight loss), while its sympathoexcitatory effects on the cardiovascular system are maintained (Correia et al., 2002; Mark et al., 2002; Rahmouni et al., 2005). Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.