Studies showed that Fe can accumulate in Aβ plagues (Shore et al., 1984; Jeandel et al., 1989; Molaschi et al., 1996; Gonzalez et al., 1999) and neurons with neurofibrillary tangles (Gonzalez-Dominguez et al., 2014), bind with the iron-responsive element RNA stem loop in the 5′-UTR of amyloid-β protein precursor (AβPP) mRNA, and then regulate the translation of AβPP (Molina et al., 1998; Squitti et al., 2013b) and AD progression. Here, APP is linked to Alzheimer disease.