PRRT2 and Alzheimer disease: For example, a deficiency of PKC in AD brains may reduce the phosphorylation of Ser655 and ectodomain (Wang et al., 1994), promoting Aβ generation (Buxbaum et al., 1990), while PKC-induced increased α-secretase cleavage in the TGN results in the reduction of β-cleavage and Aβ generation (Skovronsky et al., 2000).