Overexpression of APP results in the elevation of Aβ levels, which is also implicated in AD pathogenesis (Brouwers et al., 2006; Rovelet-Lecrux et al., 2006, 2007; Sleegers et al., 2006; Ryoo et al., 2007; Kasuga et al., 2009; Sun et al., 2011, 2014; Long et al., 2012; Wu and Song, 2013; Yang et al., 2013; Wu et al., 2014, 2015; Song et al., 2015). The gene discussed is APP; the disease is Alzheimer disease.