Dysregulation of multiple kinases and phosphatases has been observed in AD brains, including GSK3, PKC, DYRK1A, PP1, PP2A (Wang et al., 1994; Pei et al., 1999; Ferrer et al., 2005; Braithwaite et al., 2012). This evidence concerns the gene DYRK1A and Alzheimer disease.