In addition, DS patients with an extra copy of APP gene show the increase of APP expression and Aβ generation in the brain, which is associated with the development of AD neuropathology (Ryoo et al., 2007; Sun et al., 2011, 2014; Wu and Song, 2013; Wu et al., 2014, 2015; Song et al., 2015). This evidence concerns the gene APP and Dravet syndrome.