Therefore, alterations in the expression level and phosphorylation state of CRMP-2, which lead to its functional changes, are likely related to various neurological diseases including Alzheimer’s disease (AD; Wang et al., 2013; Hensley and Kursula, 2016), ischemia (Chung et al., 2005), epilepsy (Wilson et al., 2014), schizophrenia (Liu et al., 2014) and alcohol-drinking behaviors (Liu et al., 2017). This evidence concerns the gene DPYSL2 and Alzheimer disease.