These findings demonstrate that mTOR pathways could also control CRMP-2 expression and synaptic activity in PTZ-induced epileptic rat brain tissues, similar to that observed in cultured neuronal cells, implicating the potentially important role of CRMP-2 regulated by mTOR in epilepsy, although significant changes by rapamycin in the PTZ-induced behavioral seizure activity were not observed in this study. The gene discussed is MTOR; the disease is epilepsy.