FBXW7 encodes a member of the F box protein family and is frequently deleted/mutated in cancer, supporting its tumor-suppressive function (Davis et al., 2014); notably in relation to H3.3G34R/V it has been reported to play a role in MYC/MYCN stabilization through its action as a component of the SCF-like ubiquitin ligase complex that targets MYC/MYCN for proteasomal degradation (Welcker et al., 2004, Yada et al., 2004). This evidence concerns the gene MYC and cancer.