Common large-scale chromosomal alterations with prognostic significance included loss of 17p (n = 156), which targets TP53 at 17p13.1 and confers a shorter overall survival in tumors of all locations and all subgroups (Figure S3B), and gains of 9q (n = 108), more broadly encompassing a region of structural rearrangement on 9q34 in medulloblastoma (Northcott et al., 2014), and correlating with shorter overall survival in multiple pHGG/DIPG subgroups (Figure S3C). This evidence concerns the gene TP53 and medulloblastoma.