In contrast, although an improvement in steatosis and hepatic cell ballooning may be observed within the first year after these procedures, in a prospective study including 381 patients, although 95.7% maintained a fibrosis score ≤ F1, fibrosis had progressed significantly after 5 years, and was associated with higher BMIs and increased insulin resistance [9]. The gene discussed is INS; the disease is steatosis.