In all patients with pNETS a thorough history and examination should be carried out, in particular looking for features of the syndromic associations of GEP-NETs; a skin examination may reveal lipomas/angiomas/lipomas/hypopigmented macules or gingival papules [40] (suggesting MEN1), or café-au-lait spots (suggesting NF1). Here, NF1 is linked to lipoma.