The diagnosis should be strongly suspected in patients with a family history of an MEN1 associated disease (primary hyperparathyroidism, pituitary adenoma, pancreatic NET, Zollinger-Ellison syndrome) or in those a family history of renal colic, early onset peptic-ulcer disease or sudden unexplained death in younger members of the family. This evidence concerns the gene MEN1 and pancreatic neuroendocrine tumor.