The top targets for antipsychotics (with highest association with schizophrenia) are DRD2, CHRM4 and HTR5A; for antiepileptics, CACNA1I and SCN9A, and for selective calcium channel blockers, CACNA1C and CACNB2. The top genes in epilepsy pathways are AKT3, GABBR2, and KCNQ2, and the main target families are GABA receptors, glutamate receptors, potassium channels, sodium channels, and calcium voltage-gated channels (Fig. 4b). Here, CACNA1I is linked to schizophrenia.