Roles for NFκB and mutp53 in the regulation of each other’s binding at active enhancers in response to chronic TNF signaling is supported by our demonstration of (1) direct physical interactions between purified NFκB and mutp53, (2) the formation of mutp53 and NFκB associations in colon cancer cells, and (3) the decreased binding of NFκB and mutp53 at active enhancers that occurs following the depletion or inactivation of the other factor. Here, TNF is linked to malignant colon neoplasm.