To investigate the mechanisms underlying the roles of mutp53 in promoting chronic inflammation-induced tumorigenesis, we performed mRNA sequencing (mRNA-seq) in human SW480 colon cancer cells expressing doxycycline-inducible short hairpin RNAs (shRNAs) against mutp53 before and following TNF-α treatment for 16 h. Here, TNF is linked to malignant colon neoplasm.