TP53 and breast cancer: The TNF-α-inducible gene-selective effects of mutp53 were also identified when using an siRNA oligonucleotide that is directed against a different region of p53 mRNA in SW480 cells (Supplementary Fig. 1a) and in breast cancer MDA-MB-231 cells that express mutp53 R280K (Supplementary Fig. 1b).