Notably, this cell-killing effect of B220 was more prominent in HCT116 colorectal cancer cells than in prostate cancer PC3 and non-small-cell lung cancer A549 cells (Fig. 1A and B), making HCT116 cells an appropriate model for assessing the effects of B220 and its underlying molecular mechanism of action. The gene discussed is PTPRC; the disease is prostate carcinoma.