The MTHFR gene polymorphism elevated stroke prevalence in several conditions, including hypertension, diabetes mellitus, hyperlipidemia, smoking, high density lipoprotein-cholesterol levels, triglyceride levels, folate levels ≤3.45 nmol/mL, and tHcy levels ≥11.22 μmol/L (Table 2). This evidence concerns the gene MTHFR and hypertensive disorder.