The MTHFR 2572 C > A and 6685 T > C polymorphisms were shown to increase the risk of embolisms of cardiac origin and ischemic stroke occurrence, and the prevalence of large-artery-origin ischemic stroke had a decreased odds ratio (OR) for the MTHFR 6685 T > C polymorphism. Here, MTHFR is linked to ischemic stroke.