In addition, the MTHFR 4869CG + GG genotype had a combinatorial effect with hypertension (AOR, 3.217; 95% CI, 1.763–5.872) and smoking (AOR, 5.067; 95% CI, 1.788–14.360), whereas the MTHFR 5488CT + TT genotype was significant only in the smoking group (AOR, 2.740; 95% CI, 1.196–6.278). Here, MTHFR is linked to hypertensive disorder.