VIL1 and intestinal obstruction: In contrast to reports of conventional TMEM16A-defiicent mice4,19, the Vil1-Cre–TMEM16Aflox/flox mice did not show any difference in birth rate or lifespan, or manifest any baseline intestinal abnormalities (including intestinal obstruction or change in faecal water content) compared to control TMEM16A wild-type (wt) mice (Vil1-Cre–TMEM16Awt/wt) (Fig. S2).