These included: (1) ZNF652 (zinc finger protein 652), which has a tumor suppressive function31, (2) SATL1 (spermidine/spermine N1-acetyl transferase-like 1 protein), which has a role in the ubiquitination and degradation of HIF-1a which in turn has a critical role in angiogenesis32, and (3) CDKN1A (cyclin-dependent kinase inhibitor 1 A, also known as p21), which has a critical role in cell survival33 (Fig. 6b; Supplementary Fig. 7b, c). Here, HIF1A is linked to neoplasm.