This possibility is supported by our finding that Zfp296 deficiency did not affect the frequency of spontaneous tumorigenesis and lifespan; however, the role of Zfp296 loss in the pathogenesis of oligodendroglioma and prostate carcinoma in which Zfp296 is epigenetically silenced is still not known19,20. This evidence concerns the gene ZNF296 and oligodendroglioma.