MTOR and malignant colon neoplasm: Indeed, isogenic HCT116-human colon cancer cells expressing wild-type (HCT116 MW) and rapamycin-resistant S2035I mutants of MTOR (HCT116 MM) showed a similar sensitivity to the leucine signaling inhibitor, whereas HCT116 MM cells showed a reduced sensitivity to rapamycin (Fig. 7a, d).