As shown in Figure S6a, Annexin A2 mRNA level was significantly elevated in hepatocellular carcinoma (P < 0.001) and the ROC curve generated based on the mRNA level of Annexin A2 indicated that Annexin A2 can be a biomarker of high accuracy (AUC > 0.9) in hepatocellular carcinoma (Figure S6b). The gene discussed is ANXA2; the disease is hepatocellular carcinoma.