ANXA2 and cancer: Plate clone formation assay also clearly showed that Annexin A2-K302A transfectants prevented (20S)G-Rh2 induced cell death much more significantly than wild-type Annexin A2 transfectants (Fig. 5e), suggesting that the anti-survival activity of (20S)G-Rh2 on cancer cell was primarily executed by targeting Annexin A2 in HepG2 cells.