In the present study, the expressions of autophagy protein LC3-II, Beclin-1, ATG5, ATG7, Caspase12, and Caspase-3 in lung tissues were significantly higher, but the p62 expression was lower in the 3-MA intervention and CQ intervention groups compared with the COPD group. This evidence concerns the gene ATG5 and chronic obstructive pulmonary disease.