On the other hand, it has been reported that, particularly in hematological malignancy including MM, based on the high expression of DR4/DR5 molecules, the soluble TRAIL isoform is also capable of inducing apoptosis in a similar manner, although less effective, than in the membrane bound form as presented by the transduced cells [40]. The gene discussed is TNFRSF10B; the disease is Miyoshi myopathy.