To this, we adopted the retroviral bicistronic vector pMIGR1 incorporating the full-length TRAIL gene whose expression is regulated by pIL6. Several cytokines such as IL-1α and IL-1β are largely secreted by MM cells within the marrow microenvironment to activate the IL-6 secretion by BM MSCs [41–43] through the stimulation of its own promoter by EGR-1 [23, 24, 44]. This evidence concerns the gene IL1B and Miyoshi myopathy.