During the tumor progression of myeloma within the bone marrow, indeed, both interleukin (IL)-1α and IL-1β secreted by MM cells stimulate the stroma to produce IL-6 [23] through the linkage of the early growth response (EGR)-1 protein to the promoter of IL-6 (pIL6) [24]. The gene discussed is IL6; the disease is plasma cell myeloma.