Therefore, we transduced the UC-MSCs with a vector containing the full-length cDNA sequence of TRAIL under the control of the pIL6 and we evaluated the potential of pIL6-TRAIL+-GFP+-UC-MSCs to eradicate MM cells both in vitro and in SCID mice bearing intratibial human myeloma. The gene discussed is TNFSF10; the disease is plasma cell myeloma.