AD is believed to be caused by the accumulation of aggregated amyloid β (Aβ) peptides and phosphorylated tau (P-tau) proteins in the brain, which is reflected by low cerebrospinal fluid (CSF) levels of Aβ42 and high levels of total tau (T-tau) and P-tau, respectively [2, 3]. Here, MAPT is linked to Alzheimer disease.