In addition, neonatal primary astrocytes derived from a mouse model of ALS (hSOD1G93A) were found to express higher levels of reactivity markers and β3 Integrin, Syndecan-4, Connexin-43, and Pannexin-1 than those derived from wild-type non-transgenic littermates. Here, PANX1 is linked to amyotrophic lateral sclerosis.