To investigate the effect of the 378C>G mutation at the cellular level, we performed in silico analysis of the p53 and the cell line databases and found three cell lines containing the same mutation: ECV-304—initially described as a spontaneously transformed cell line derived from a Japanese human umbilical vein endothelial cell culture; EJ and T24 –both are urinary bladder carcinoma. The gene discussed is TP53; the disease is urinary bladder carcinoma.