The present study mainly focused on the analysis of synergistic effects of three functional SNPs of MMP1 (rs1799750) -1607 1G/2G, MMP3 (rs35068180) -1171 5A/6A and MMP9 (rs3918242) -1562 C/T genes in relation to breast cancer development and progression. This evidence concerns the gene MMP3 and breast carcinoma.