The frequencies of the three MMP3 genotypes in controls were 29.3% (5A/5A), 57.0% (5A/6A) and 13.7% (6A/6A) while, in BC patients the frequencies were 19.7% (5A/5A), 63% (5A/6A) and 17.3% (6A/6A) and there was a deviation from those expected from the Hardy Weinberg equilibrium (p = 0.004, p = 0.0001, for controls and cases respectively). This evidence concerns the gene MMP3 and breast cancer.