It was shown using the Eμ-Myc transgenic mouse model of human BL (which expresses a c-Myc;Ig transgene) that blocking apoptosis through enforced expression of BCL-2 prosurvival proteins or deletion of BH3-only proteins or BAX greatly accelerates lymphoma development.4, 5, 6, 7. This evidence concerns the gene MYC and lymphoma.