This mechanism of action is supported by several previous studies indicating a stimulatory effect on bone catabolism11, 30, 31 and inhibitory effect on bone anabolism.11, 32, 33 Furthermore, periodontal immigration of B- and T-lymphocytes, which are primary sources of RANKL34 during periodontitis, may have been significantly reduced by the observed decline of IL-8 expression (chemokine).35 Here, CXCL8 is linked to periodontitis.