The novel discovery of Meis2 as critical to MN1-induced leukemic activity compels further investigation to unravel the basis for the profound upregulation of Meis2 in MN1 leukemias, delineate potential functional differences between MEIS2 and MEIS1, and stimulates further study into the role of MEIS2 in additional leukemic settings. Here, MEIS1 is linked to leukemia.