Further highlighting Meis2 is its previous identification as among the top-ranked genes upregulated between both MN1 and MN1Δ1(ref. 14) and MN1 and MN1VP16.25 Moreover, MEIS2 is upregulated in the leukemia-initiating cell-containing CD34+GPR56+(ref. x35) fraction of a human cord blood model of AML characterised by overexpression of MN1 and NUP98-HOXD13(ref. 15) (Figure 4bi), as well as two independently derived MN1 murine cell lines (Figure 4bii). This evidence concerns the gene ADGRG1 and acute myeloid leukemia.