Intriguingly, data from patients with normal karyotype AML (n=48) from the Leucegene RNA-Seq data set23 show that IRF8, which is repressed by MN1,25 is among the top 10 genes negatively correlated with MEIS2 expression (r=−0.61) (Figure 5e, Supplementary Figure S6B), Additionally, many of the other top 10 negatively correlated genes have important roles for immune function and thus, underline the immune suppressive function of MN1 signalling. Here, MN1 is linked to acute myeloid leukemia.