Analysis of an in-house data set comprised of patients with AML, MDS, therapy-related AML (tAML) or therapy-related MDS (tMDS), AML subsequent to MDS was consistent with an inverse correlation between HOXA9 and MEIS1 expression compared to expression of MN1 (Welch’s two-sample t-test, P<0.05) (Figure 5d). Here, HOXA9 is linked to acute myeloid leukemia.