MEIS2 and leukemia: Knockdown of Meis2 significantly increases the latency of disease in both MN1 leukemic models, with median latency of disease onset increasing from 41 to 50 days in the leukemia-derived MN1 model (Mantel–Cox, P=0.001) and from 47 to 55 days in the primary MN1 cell line model (Mantel–Cox, P=0.0119) (Figure 5a).