RUNX1 and acute myeloid leukemia: To investigate if MEIS2 upregulation could be detected in broader data sets of malignant hematopoietic subsets, we examined the TCGA AML and Leukemia MILE data sets.24 These larger data sets show upregulation of MEIS2 in both AML characterised by inv16 and RUNX1-RUNX1T1(ref. 24) (Supplementary Figure S6A).