Although knowledge about lncRNAs in the antioxidant response is limited, a recent study showed that NFE2L2 mediates activation of SCAL1 lncRNA in response to cigarette smoke58, and SCAL1 and other lncRNAs were subsequently shown to correlate with NFE2L2 mutations in lung cancer data from TCGA (ref. 21). The gene discussed is NFE2L2; the disease is lung cancer.