Similarly, inhibition of Notch1 in T-cell acute lymphoblastic leukaemia identified lncRNAs acting as downstream targets and effectors of Notch signalling17, and both overexpression and siRNA silencing of MYC, followed by transcriptomic profiling, has been used to identify long non-coding RNAs acting downstream of c-Myc (refs 18, 19). Here, MYC is linked to T-cell acute lymphoblastic leukemia.