Importantly, by comparison with available microarray data from A549 lung cancer cells treated with siRNA against NFE2L2 (ref. 44) we found that most NFE2L2-associated mRNAs detected in ≥2 cancers, and all detected in ≥4 cancers, were repressed 24 h post transfection (Fig. 3d). The gene discussed is NFE2L2; the disease is cancer.