CD4 and tuberculosis: In order to reduce the chance of developing IRIS, guidelines recommend that ART-naïve patients with CD4 counts ≥50 cells/mm3 initiate ART usually in 2 to 4 weeks, but within 8 weeks, of starting TB treatment.7 On the other hand, the benefits of immediate ART, within 2 weeks, are believed to outweigh the risk of developing IRIS in patients with CD4 counts <50 cells/mm3.