IGHE and anaphylaxis: In conclusion, treatment with A. paniculata extract did not induce clinical signs of anaphylaxis in guinea pigs and also did not induce allergic mediators release from IgE sensitized and non-IgE sensitized RBL-2H3 cells indicating that A. paniculata extract does not have anaphylactic and anaphylactoid potential under the conditions tested in the present study.