Further, the anaphylactic and anaphylactoid potential was investigated by measuring the release of allergic mediators such as histamine, β-hexosaminidase, leukotriene C4 (LTC4) and tryptase in IgE sensitized and non-IgE sensitized rat basophilic leukemia (RBL-2H3) cell line. Here, IGHE is linked to leukemia.