IGHE and allergic disease: Molecular allergy diagnosis using singleplex allergens or multiplex allergen microarrays are typical methods of precision medicine [48] and they enhance the specificity of IgE-diagnosis in polysensitized respiratory allergies [49], can be applied in food allergies [36, 50] and atopic eczema [36, 37], and may even reveal unexplained anaphylaxis [3].