CCND1 and cancer: Pal-Bhadra and coworkers have shown the effect of‏ chrysin and its analogues on cell viability and cell‏ cycle analysis by MTT assay and flow cytometry.‏ They elucidated that chrysin possess potent in vitro anti-cancer activity via suppression of the cell proliferation,‏ induction G1 cell cycle arrest, along with the up‏ regulation of p21, in addition to reduction of cyclin D1‏ and Cdk2 protein levels (32).‏